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pentobarbital will decrease the extent or influence of verapamil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will decrease the extent or impact of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Powerful CYP3A4 inducers could lower midostaurin c